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About This Item
Empirical Formula (Hill Notation):
C123H212N44O35S1
Molecular Weight:
2899.34
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥72%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
General description
Orexin B consists of an amidated C-terminus and shares 46% sequence identity with orexin-A, mainly in the C-terminal region. Orexin-B is proteolytically cleaved from the precursor prepro-orexin.
Biochem/physiol Actions
Orexin-A and Orexin-B are orexigenic peptides that mediate their effects via two receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexins are involved in food intake, obesity regulation, energy homeostasis, and differentiation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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J E Digby et al.
The Journal of endocrinology, 191(1), 129-136 (2006-10-27)
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body
Manja Lang et al.
Journal of medicinal chemistry, 47(5), 1153-1160 (2004-02-20)
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To
Masayuki Ikeda et al.
PloS one, 4(11), e7737-e7737 (2009-11-10)
THE SLEEP SEQUENCE: i) non-REM sleep, ii) REM sleep, and iii) wakefulness, is stable and widely preserved in mammals, but the underlying mechanisms are unknown. It has been shown that this sequence is disrupted by sudden REM sleep onset during
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