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Key Documents

SAB4500397

Sigma-Aldrich

Anti-Collagen XIII α1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CODA1, COLXIIIA1, Collagen α-1(XIII) chain

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 69 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500

NCBI accession no.

Q5TAT6

UniProt accession no.

Q5TAT6

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL13A1(1305)

General description

The COL13A1 (collagen type XIII α-1 chain) gene is mapped to human chromosome 10q22.1. It codes for the α-chain of a group of non-fibrillar collagen. The protein is homotrimeric containing a single transmembrane region with intracellular and extracellular domains. The ectodomain contains three alternating collagenous and non-collagenous domains. COL13A1 is expressed in the muscle motor endplate. Anti-Collagen XIII α1 Antibody detects endogenous levels of total Collagen XIII α1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen XIII alpha1.

Immunogen Range: 641-690

Biochem/physiol Actions

Collagen XIII α1 (COL13A1) is an oncogene, promoting invasion in cancer. Upregulation of COL13A1 gene is observed in bladder cancer. COL13A1 is associated with neuromuscular junction organization. Mutation in the gene leads to myasthenic disorder.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Type XIII collagen and some other transmembrane collagens contain two separate coiled-coil motifs, which may function as independent oligomerization domains
Latvanlehto A, et al.
The Journal of Biological Chemistry, 278(39), 37590-37599 (2003)
Diagnostic and prognostic role of urinary collagens in primary human bladder cancer
Miyake M, et al.
Cancer Science, 108(11), 2221-2228 (2017)
Congenital myasthenic syndrome type 19 is caused by mutations in COL13A1, encoding the atypical non-fibrillar collagen type XIII alpha1 chain
Logan CV, et al.
American Journal of Human Genetics, 97(6), 878-885 (2015)
Clinical and genetic basis of congenital myasthenic syndromes
PVS DeSouza, et al.
Arquivos de Neuro-Psiquiatria, 74(9), 750-760 (2016)

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