SAB4200058

Anti-Rab13 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-GIG4, Anti-Growth-inhibiting gene 4 protein, Anti-RAS-associated protein RAB13
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: IF; IP; WB
• clone: polyclonal
• species reactivity: human
• citations: 5
• technique(s): immunoprecipitation (IP): 5-10 μg using lysates of human NT2 cells; indirect immunofluorescence: 2-5 μg/mL using human A431 cells; western blot: 5-10 μg/mL using whole extracts of human NT2 cells

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~23 kDa
• species reactivity: human
• packaging: antibody small pack of 25 μL
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 5-10 μg using lysates of human NT2 cells; indirect immunofluorescence: 2-5 μg/mL using human A431 cells; western blot: 5-10 μg/mL using whole extracts of human NT2 cells
• UniProt accession no.: P51153
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RAB13(5872)

Description

General description

Rab (Ras-related in brain) 13 is encoded by the gene mapped to human chromosome 1q21.3. It is a member of Rab family of proteins. The encoded protein is ubiquitously expressed and is mainly localized at the trans-Golgi network, on recycling endosomes, on late endosomes, and at the plasma membrane.

Application

Anti-Rab13 (C-terminal) antibody produced in rabbit has been used in:

• immunoprecipitation
• immunofluorescence
• western blotting

Biochem/physiol Actions

Rab (Ras-related in brain) 13 plays a vital role in both biosynthetic and endosomal recycling pathways. It is also involved in the regulation of membrane trafficking at the level of endosomes. Rab13 helps in the transport of cargo (integrins) to the plasma membrane, disruption of cell-cell adhesions. Additionally, it aids in cell migration by rearranging actin cytoskeleton attached to surface delivery of selective proteins. It also plays a crucial role in cancer progression. Rab13 is also involved in a putative secretory function in osteoclasts.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable