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SAB1100972

Sigma-Aldrich

Anti-HSPB3 (11-25) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-HSPL27, Anti-Heat shock protein β-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~17 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1:500-1:2,000

UniProt accession no.

Q12988

General description

Heat shock protein family B (small) member 3 (HSPB3) is a member of HSPB family. It is expressed in skeletal and cardiac muscles. HSPB3 gene is located on human chromosome location 5q11.2.

Immunogen

synthetic peptide corresponding to amino acids 11-25of human HSPB3

Application

Anti-HSPB3 (11-25) antibody produced in rabbit has been used in western blotting and immunoelectron microscopy.

Biochem/physiol Actions

Heat shock protein family B (small) member 3 (HSPB3) has molecular chaperone-like activity in inhibiting the heat-induced aggregation of alcohol dehydrogenase (ADH). HSPB is critical for the development and maintenance of muscles. Mutations in HSPB3 are associated with distal hereditary motor neuropathy type 2C (dHMN2C).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
068M4825V
054M4754V
054M4754
010M2839

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HspB3, the most deviating of the six known human small heat shock proteins
Boelens WC, et al.
Biochimica et Biophysica Acta, Protein Structure and Molecular Enzymology, 1388(2), 513-516 (1998)
Federica F Morelli et al.
Cell stress & chaperones, 22(4), 531-540 (2017-02-10)
The ten mammalian small heat shock proteins (sHSPs/HSPBs) show a different expression profile, although the majority of them are abundant in skeletal and cardiac muscles. HSPBs form hetero-oligomers and homo-oligomers by interacting together and complexes containing, e.g., HSPB2/HSPB3 or HSPB1/HSPB5
The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells
Piccolella M, et al.
Oncotarget, 8(6), 10400-10400 (2017)
An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8
Morelli FF, et al.
Cell Stress & Chaperones, 22(4), 531-540 (2017)
Veronica La Padula et al.
Experimental neurology, 286, 40-49 (2016-10-23)
The human small heat shock proteins (HSPBs) form a family of molecular chaperones comprising ten members (HSPB1-HSPB10), whose functions span from protein quality control to cytoskeletal dynamics and cell death control. Mutations in HSPBs can lead to human disease and
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