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S1688

Sigma-Aldrich

SR 57227A

solid

Synonym(s):

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H14ClN3 · HCl
CAS Number:
77145-61-0
Molecular Weight:
248.15
MDL number:
MFCD01756430
UNSPSC Code:
12352200
PubChem Substance ID:
24278109
NACRES:
NA.77
Pricing and availability is not currently available.

form

solid

color

white

solubility

H2O: soluble 9 mg/mL

SMILES string

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

InChI key

FUMINTAAUJUVMP-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

Application

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Biochem/physiol Actions

Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors[1] and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells.[2] It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.[3]

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
035M4605V
054M4616V
125K46053
125K46052
125K46051

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L Staner et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 11(4), 301-305 (2001-09-05)
The respective role of various classes of central serotonin (5-HT) receptors in the regulation of sleep-wakefulness cycles has been the subject of many studies. Notably, it has been reported that 5-HT1A/B receptors are involved in the regulation of rapid eye
J Y Zhang et al.
Neuropharmacology, 33(3-4), 483-491 (1994-03-01)
The techniques of extracellular single cell recording and microiontophoresis were used to study the effect of 5-HT3 receptor agonists on glutamate-activated firing of CA1 hippocampal pyramidal cells. Iontophoretic application of 5-HT3 receptor agonists 2-methyl-5-HT and SR 57227A produced a current
Takahiro Hayashi et al.
Neuroscience research, 66(1), 22-29 (2009-09-22)
The serotonin type 3 (5-HT(3)) receptor is an only ligand-gated ion channel among 14 serotonin receptors. Here, we examined the roles of the 5-HT(3) receptor in the formation of dendrites and axons, using a dissociation culture of embryonic rat cerebral
Z H Gui et al.
Neuroscience, 169(3), 1315-1325 (2010-06-26)
In the present study, we examined changes in the firing rate and firing pattern of putative slow-spiking (SS) and fast-spiking (FS) interneurons in medial prefrontal cortex (mPFC) and the effect of 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist SR 57227A on the neuronal
E Edwards et al.
Brain research, 733(1), 21-30 (1996-09-09)
The aim of the study was to further characterize the pharmacological properties of 5-hydroxytryptamine (5-HT)3-like receptors in the rat medial prefrontal cortex (mPFC) using combinations of biochemical and electrophysiological approaches. Phenylbiguanide (PBG) and three chlorinated derivatives, ortho-chloro-PBG (oCPBG), meta-chloro-PBG (mCPBG)
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