Serotonin 5-HT4 receptor (HTR4) gene with five exons spanning ∼1.3 Mb, is mapped to human chromosome 5q32. The protein is majorly found in the central nervous system, mainly in limbic structures. HTR4 protein is also expressed in lower levels in various types of tissues including esophagus, ileum, colon, adrenocortical cells, urinary bladder, and heart. HTR4 belongs to the G protein-coupled receptor (GPCR) superfamily. Anti-Serotonin 5-HT4 receptor specifically recognizes human serotonin 5-HT4 receptor.
synthetic peptide corresponding to the third cytoplasmic loop of human serotonin 5-HT4 receptor, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 94% homology with the mouse gene.
Biochem/physiol Actions
Serotonin 5-HT4 receptor (HTR4) plays a vital role in psychomotor function and regulation of dopamine secretion. In the central nervous system, HTR4 aids in learning and memory, depression, anxiety, and feeding behavior. HTR4 gene polymorphism leads to the development of asthma, attention-deficit/hyperactivity disorder (ADHD), mood disorders, and schizophrenia.
Physical form
Solution in phosphate buffered saline containing 0.1% sodium azide.
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Possible irregularities in serotonergic neurotransmission have been suggested as causes of a variety of neuropsychiatric diseases. We performed mutation and association analyses of the HTR4 gene, on 5q32, encoding the serotonin 4 receptor in mood disorders and schizophrenia. Mutation analysis
The neurotransmitter, 5-hydroxytryptamine, acts as an immunomodulator by stimulating the release of inflammatory cytokines and regulating the function of dendritic cells and monocytes. The 5-hydroxytryptamine receptor 4 (HTR4) gene is located in a region previously linked to an increased risk
Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT₄R) gene (HTR4) associated with lung function. The aims of this study were to i) investigate the expression profile of HTR4 in adult
Attention-deficit/hyperactivity disorder (ADHD) is an important public health problem. Although serotonin is believed to be an important neurotransmitter in the etiology of this disorder, it remains unclear which specific 5-HT receptors are involved in regulating the symptoms of ADHD. Previous
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