RAB0028
Human BMP2 ELISA Kit
for serum, plasma, cell culture supernatant and urine
Synonym(s):
BMP-2, Bone morphogenetic protein 2
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All Photos(2)
About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type serum
sample type cell culture supernatant(s)
sample type urine
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 45 pg/mL
standard curve range: 46.88-3000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BMP2(650)
General description
BMP2 (bone morphogenetic protein 2) is encoded by the gene mapped to human chromosome 20p12.3. The encoded protein belongs to transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in heart, lung, and dorsal aorta.
The Human BMP-2 ( Bone morphogenetic proteins-2) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme- linked immunosorbent assay for the quantitative measurement of human BMP-2 in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Human BMP2
Application
For research use only. Not for use in diagnostic procedures.
Human BMP2 (bone morphogenetic protein 2) ELISA kit has been used for measuring concentrations of BMP in conditioned mouse organoid media.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human BMP2 (bone morphogenetic protein 2) ELISA kit has been used for measuring concentrations of BMP in conditioned mouse organoid media.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
BMP2 (bone morphogenetic protein 2) plays a vital role in the activation of the autonomic lineage-specific basic–helix-loop-helix protein MASH1 (mammalian achaete scute homolog-1) and in the autonomic neurogenesis in neural crest stem cells in vitro. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. Recombinant human bone morphogenetic protein-2 (rhBMP-2) plays an essential role in pathogenesis of oral squamous cell carcinomas. Mutation in BMP-2 gene is associated with osteoporosis.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Yingnan Geng et al.
Communications biology, 4(1), 82-82 (2021-01-21)
Bone has a remarkable potential for self-healing and repair, yet several injury types are non-healing even after surgical or non-surgical treatment. Regenerative therapies that induce bone repair or improve the rate of recovery are being intensely investigated. Here, we probed
Khaled Waleed Zaid et al.
Asian Pacific journal of cancer prevention : APJCP, 17(3), 927-932 (2016-04-05)
Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including cell migration, differentiation, adhesion, proliferation and apoptosis. Use of recombinant human bone morphogenic protein?2 (rhBMP?2) in oral and maxillofacial surgery has seen a tremendous
R E De la Vega et al.
European cells & materials, 40, 160-171 (2020-10-07)
There is much interest in understanding the influence of the immune system on bone healing, including a number of reports suggesting a beneficial effect of FK506 (tacrolimus) in this regard. The influence of FK506 in a rat, femoral, critical size
Rishi Man Chugh et al.
International journal of molecular sciences, 22(17) (2021-09-11)
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Previous studies have demonstrated the therapeutic efficacy of human bone marrow mesenchymal stem cells (BM-hMSCs) for PCOS; however, the regulatory mechanism remains unknown. Bone morphogenetic proteins (BMPs) secreted
Maria Godoy-Gallardo et al.
International journal of molecular sciences, 21(17) (2020-09-10)
We have previously reported the fabrication of a polycaprolactone and hydroxyapatite composite scaffold incorporating growth factors to be used for bone regeneration. Two growth factors were incorporated employing a multilayered coating based on polydopamine (PDA). In particular, Bone morphogenetic protein-2
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