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K4144

Sigma-Aldrich

KB-R7943

≥98% (HPLC), powder

Synonym(s):

2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1), Carbamimidothioic acid

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About This Item

Empirical Formula (Hill Notation):
C16H17N3O3S·CH3SO3H
CAS Number:
182004-64-4
Molecular Weight:
427.50
MDL number:
MFCD00952138
UNSPSC Code:
12352200
PubChem Substance ID:
329817144
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

off-white to tan

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1

InChI

1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)

InChI key

WGIKEBHIKKWJLG-UHFFFAOYSA-N

Biochem/physiol Actions

KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lorena Halty-deLeon et al.
Frontiers in cellular neuroscience, 12, 186-186 (2018-07-19)
CALX, the Na+/Ca2+ exchanger in Drosophila, is highly expressed in the outer dendrites of olfactory sensory neurons (OSNs) which are equipped with the odorant receptors (ORs). Insect OR/Orco dimers are nonselective cation channels that pass also calcium which leads to
Pascaline Clerc et al.
PloS one, 7(4), e34465-e34465 (2012-04-13)
Mitochondrial dysfunction is a component of many neurodegenerative conditions. Measurement of oxygen consumption from intact neurons enables evaluation of mitochondrial bioenergetics under conditions that are more physiologically realistic compared to isolated mitochondria. However, mechanistic analysis of mitochondrial function in cells
Ignacio Ibáñez et al.
Neurochemistry international, 123, 125-132 (2018-03-27)
GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internalization from the surface
Camille Loubiere et al.
Scientific reports, 7(1), 5040-5040 (2017-07-13)
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent
Reno C Reyes et al.
ASN neuro, 4(1) (2012-01-25)
Astroglial excitability operates through increases in Ca2+cyt (cytosolic Ca2+), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na+cyt (cytosolic Na+) control metabolic neuronal-glial signalling, most notably through stimulation of lactate production, which on release from astrocytes can
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