I0911
IRR (945-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
INSRR
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
94-128 nmol/min·mg
mol wt
~65 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... INSRR(3645)
General description
IRR (insulin receptor-related receptor) belongs to the insulin receptor (IR) family. It is expressed in neuronal tissues, kidney, pancreas and stomach.
Biochem/physiol Actions
IRR or insulin receptor-related receptor is a tyrosine protein kinase. IRR is an extracellular pH sensor. The IRR mRNA is present in neuroblastomas and may be associated with tumor genesis.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Igor E Deyev et al.
The Journal of biological chemistry, 288(47), 33884-33893 (2013-10-15)
IRR is a member of the insulin receptor (IR) family that does not have any known agonist of a peptide nature but can be activated by mildly alkaline medium and was thus proposed to function as an extracellular pH sensor.
B Zhang et al.
The Journal of biological chemistry, 267(26), 18320-18328 (1992-09-15)
In 1989, Shier and Watt identified a gene which was predicted to encode a new member of the insulin receptor (IR) family, and they called it the insulin receptor-related receptor (IRR) (Shier, P., and Watt, V. M. (1989) J. Biol.
M W Elmlinger et al.
Regulatory peptides, 84(1-3), 37-42 (1999-10-27)
The insulin receptor-related receptor (IRR) is a member of the insulin receptor family. So far no ligand has yet been discovered for this receptor type (orphan receptor). IRR, insulin receptor (IR), and insulin-like growth factor-I receptor (IGF-I-R) are all tyrosine
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