GW22561

Anti-SNX2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• MDL number: MFCD02264101
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human, rat
• technique(s): western blot: suitable
• NCBI accession no.: NP_003091.1
• UniProt accession no.: O60749
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SNX2(6643)

Description

General description

SNX2 (sorting nexin 2) is a member of cytoplasmic and membrane proteins called SNXs. This protein is expressed in thyroid in the columnar and active follicular cells. It contains the PX (phox homology) domain, found in all SNX members, which binds to phosphatidylinositol 3-phosphate (PI3P). It also contains a BAR domain adjacent to its PX domain, towards the C-terminal. It is thought to form a dimer with other SNX member proteins, which in turn make a part of the heteropentameric complex called retromer. SNX2 also contains a coiled-coil domain in its C-terminal. It is a homologue of vacuolar protein-sorting (Vps)5p found in yeast. It has a molecular weight of ~68kDa.

Immunogen

Immunogen Sequence: GI # 4507141, sequence 1-519

Recombinant sorting nexin 2

Application

Anti-SNX2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Sorting nexin-2 (SNX2) acts as a novel marker for active thyrocytes and reflects the endosomal trafficking activity in these cells. It forms a component of the mammalian retromer complex that functions in the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans-Golgi network. It is involved, though not necessary, in the lysosomal sorting of EGFR (epidermal growth factor receptor), which is internalized. Mouse embryos with inactivated SNX2 gene die mid-gestation. This study suggests that SNX2 is essential during developmental processes.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves