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GW21007A

Sigma-Aldrich

Anti-α-2B Adrenergic Receptor antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-α-2B Adrenergic Receptor, Anti-α-2B adrenoreceptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21007A

technique(s)

western blot: suitable

NCBI accession no.

NP_000673.1

UniProt accession no.

P18089

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRA2B(151)

Immunogen

Immunogen Sequence: GI # 4501965, sequence 200-299
Recombinant α-2B-adrenergic receptor; α-2-adrenergic receptor-like 1

Application

Anti-α-2B Adrenergic Receptor antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The α-2B adrenergic receptor (α2B adrenoceptor) is a G-protein coupled receptor and is a subtype of the adrenergic receptor family. It is encoded by ADRA2B gene in humans. Mutation in this gene is associated with autosomal dominant cortical myoclonus and epilepsy (ADCME). ADRA2B influences norepinephrine activity. It helps in increasing emotional memory and neural activity. A genetic variation of the noradrenergic system may preserve emotional faces from stress-induced memory impairments under control conditions.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
039K0456
029K1666

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Shijia Li et al.
Neurobiology of learning and memory, 103, 11-18 (2013-04-16)
Previous studies have shown that acute psychosocial stress impairs retrieval of declarative memory with emotional material being especially sensitive to this effect. A functional deletion variant of the ADRA2B gene encoding the α2B-adrenergic receptor has been shown to increase emotional
Maurizio De Fusco et al.
Annals of neurology, 75(1), 77-87 (2013-10-12)
Autosomal dominant cortical myoclonus and epilepsy (ADCME) is characterized by distal, fairly rhythmic myoclonus and epilepsy with variable severity. We have previously mapped the disease locus on chromosome 2p11.1-q12.2 by genome-wide linkage analysis. Additional pedigrees affected by similar forms of
Rebecca M Todd et al.
Psychological science, 24(11), 2244-2253 (2013-09-24)
Emotionally enhanced memory and susceptibility to intrusive memories after trauma have been linked to a deletion variant (i.e., a form of a gene in which certain amino acids are missing) of ADRA2B, the gene encoding subtype B of the α2-adrenergic

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