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G4795

Sigma-Aldrich

Anti-GLUT10 (SLC2A10) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Glucose Transporter 10, Anti-Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 10

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About This Item

MDL number:
MFCD08705461
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~57 kDa by calculation

species reactivity

human

technique(s)

western blot: 1:500-1:1,000

UniProt accession no.

O95528

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SLC2A10(81031)

Immunogen

peptide corresponding to the human GLUT10 protein (amino acids 367-385).

Biochem/physiol Actions

GLUT10 is a glucose transporter that is encoded by the gene SLC2A10, and is highly expressed in liver and pancreas. Polymorphisms in SLC2A10 may not influence the pathogenesis of type 2 diabetes but the expression of GLUT10 and the interaction with TGF-β signaling pathway has important role in the development of peripheral arterial disease in patients with type 2 diabetes. GLUT10 is also required for the development of cardiovascular system and the notochord in zebrafish embryos.

Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Gitte Andersen et al.
Diabetes, 52(9), 2445-2448 (2003-08-28)
The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The
Andy Willaert et al.
Human molecular genetics, 21(6), 1248-1259 (2011-11-26)
Growth factor signaling results in dramatic phenotypic changes in cells, which require commensurate alterations in cellular metabolism. Mutations in SLC2A10/GLUT10, a member of the facilitative glucose transporter family, are associated with altered transforming growth factor-β (TGFβ) signaling in patients with
Yi-Der Jiang et al.
BMC medical genetics, 11, 126-126 (2010-08-26)
Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. We genotyped

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