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About This Item
Empirical Formula (Hill Notation):
C13H10Cl2N2O4S
CAS Number:
Molecular Weight:
361.20
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cc(ccc1NS(=O)(=O)c2cc(Cl)ccc2Cl)[N+]([O-])=O
InChI
1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChI key
AXNUEXXEQGQWPA-UHFFFAOYSA-N
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
FH535 is a reversible dual inhibitor of Wnt/β-catenin and PPARγ and PPARδ signaling antagonist; β-catenin/Tcf inhibitor.
FH535 is a reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling antagonist. FH535 is unique in its ability to inhibit the Wnt/β-catenin pathway. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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