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About This Item
Empirical Formula (Hill Notation):
C43H65N7O9
CAS Number:
Molecular Weight:
824.02
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCCN)C(O)=O
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Biochem/physiol Actions
Potent chemoattractant for human neutrophils.
Radioiodinated molecule has full biological activity.
Radioiodinated molecule has full biological activity.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Djafarzadeh et al.
Experimental cell research, 236(2), 427-435 (1997-11-21)
We have studied activation-induced dephosphorylation of proteins in human neutrophils loaded with [32P]orthophosphate using two-dimensional gel electrophoresis and autoradiography. A major phosphoprotein of 20 kDa in resting neutrophils was markedly dephosphorylated upon activation of cells with chemotactic peptide or phorbol
J F Hoffman et al.
Biochemistry, 35(40), 13047-13055 (1996-10-08)
With the aid of high time resolution kinetic data extracted from a flow cytometer, we determined that there are two N-formyl peptide receptor states for human neutrophils at 4 degrees C: a low affinity and a high affinity state. Competitive
G J Dobos et al.
The Clinical investigator, 72(5), 353-357 (1994-05-01)
We studied the effect of C5a pretreatment on phosphatidyl-inositol-4,5-bisphosphate (PIP2) hydrolysis and on the increase in peak and resting cytosolic calcium levels induced by C5a (0.1 and 10 nM) and/or N-formyl hexapeptide (FLPEP; 10 nM) in neutrophils isolated from patients
S Seveau et al.
Journal of cell science, 110 ( Pt 13), 1465-1475 (1997-07-01)
We investigated a possible association of leukosialin (CD43), the major surface sialoglycoprotein of leukocytes, with neutrophil cytoskeleton. We first analysed the solubility of CD43 in Triton X-100 and observed that CD43 of resting neutrophils was mostly soluble. The small proportion
M Keitoku et al.
Journal of molecular and cellular cardiology, 29(3), 881-894 (1997-03-01)
The chemoattractant f-Met-Leu-Phe (FMLP) can modulate human coronary arterial tone without the involvement of peripheral leukocytes. We investigated the actions of FMLP and its cellular mechanism in human coronary arteries isolated 2-3 h after death. A single dose of FMLP
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