This product is offered based on the Estradiol content. The 100 mg package size will contain 100 mg of Estradiol, however the bulk of the mass in the bottle will be 2-hydroxypropyl-β-cyclodextrin. For example, a lot reporting a 48 mg/g estradiol content will have approximately 2.08 grams of powder material in the vial. Please see the link below to review additional information regarding water-soluble complexes and cyclodextrins:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/268/198/e4389inf.pdf
E4389
β-Estradiol-Water Soluble
BioReagent, suitable for cell culture
Synonym(s):
Cyclodextrin-encapsulated 17β-estradiol
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About This Item
Biological source:
synthetic (organic)
Form:
powder
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Segment
sterility
non-sterile
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 25 mg/mL, clear to slightly hazy
shipped in
ambient
storage temp.
room temp
SMILES string
C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O.C[C@@H]5[C@@H](O)[C@@H]6O[C@H](CO)[C@H]5O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O6)[C@H](O)[C@H]%12O)[C@H](O)[C@H]%11O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8OCCCO)[C@H](O)[C@H]7O
InChI
1S/C46H78O35.C18H24O2/c1-12-20(55)40-68-13(5-48)32(12)75-41-26(61)25(60)37(18(10-53)69-41)81-46-39(67-4-2-3-47)31(66)38(19(11-54)74-46)80-45-30(65)24(59)36(17(9-52)73-45)79-44-29(64)23(58)35(16(8-51)72-44)78-43-28(63)22(57)34(15(7-50)71-43)77-42-27(62)21(56)33(76-40)14(6-49)70-42;1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12-66H,2-11H2,1H3;3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-;14-,15-,16+,17+,18+/m11/s1
InChI key
XMURHKLFGRLVRW-JKDYGSMVSA-N
General description
β-estradiol is a natural human estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics. Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells. β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis. Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.
Application
β-estradiol has been used:
- to culture differentiated adipocytes
- for estradiol treatment in rats
- for oocyte maturation in vitro
Packaging
Package size based on estradiol
Other Notes
Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.
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This Item | |||
|---|---|---|---|
| description BioReagent, suitable for cell culture | description BioReagent, powder, suitable for cell culture | description powder, γ-irradiated, suitable for cell culture | description ≥98% |
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| product line BioReagent | product line BioReagent | product line BioXtra | product line - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form powder | form powder | form powder | form powder |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable, single cell analysis: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| shipped in ambient | shipped in ambient | shipped in ambient | shipped in ambient |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - ED ENV 1 - ED HH 1 - Lact. - Repr. 1A
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Does it mean that if I dissolve the 100 mg into 4ml distilled water, I get estradiol only concentration of 25mg/ml. Also how do I prepare vehicle control for this experiment. Also what is the 48 mg/g telling
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what is the molecular weight of E-4389 product?
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This is a dual-component product. A single molecular weight does not apply. The molecular weight of the B-estradiol is 272.38 grams per mol, and the molecular weight of the 2-hydroxypropyl-β-cyclodextrin is 1396 grams per mol. The package size of 100 mg is in reference to the B-Estradiol. This product contains 40 - 50 mg per gram solid. The lot-specific B-estradiol content is reported in the Certificate of Analysis.
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What is the storage stability of E4389, β-Estradiol - Water Soluble (25 mg/mL complex) in distilled water at 4C, -20C, or -80C?
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This product is stable for 6 months at -20°C in a non-defrosting freezer after solubilizing in distilled water. There is no stability data for this product at 4°C or -80°C.
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How do I calculate the molarity of product E4389, β-Estradiol - Water Soluble?
1 answer-
Product E4389 (β-Estradiol-Water Soluble) is a complex of β-Estradiol and cyclodextrin. Cyclodextrin is used to aid in the solubility of β-Estradiol into water. In order to prepare a molar solution of β-Estradiol you will have to base it on the β-Estradiol content in the solution and not the entire complex.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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