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Dichloromethylenediphosphonic acid disodium salt

Name: Dichloromethylenediphosphonic acid disodium salt
Brand: SIGMA

osteoclastic activity inhibitor, powder

Synonym(s):

Cl₂MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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About This Item

Linear Formula:

CH₂O₆Cl₂Na₂P₂

CAS Number:

22560-50-5

Molecular Weight:

288.86

NACRES:

NA.77

PubChem Substance ID:

24278371

UNSPSC Code:

12352106

EC Number:

245-078-9

MDL number:

MFCD01632786

Form:

powder

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Properties

Product Name

Dichloromethylenediphosphonic acid disodium salt,

form

powder

Quality Segment

300

solubility

water: 49.00-51.00 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Gene Information

rat ... Man2a1(25478), Si(497756)

Description

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

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This Item	Y0000888	Y0000885	EMU003381
Sigma-Aldrich D4434 Dichloromethylenediphosphonic acid disodium salt	Y0000888 Clodronate disodium tetrahydrate	Y0000885 Clodronate impurity D	Sigma-Aldrich EMU003381 MISSION^® esiRNA
description -	description European Pharmacopoeia (EP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description targeting mouse Man2a1
form powder	form -	form -	form lyophilized powder
Quality Level 300	Quality Level -	Quality Level -	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility water: 49.00-51.00 mg/mL, clear, colorless	solubility -	solubility -	solubility -
Gene Information rat ... Man2a1(25478), Si(497756)	Gene Information -	Gene Information -	Gene Information mouse ... MAN2A1(17158), Man2a1(17158)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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