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(±)-SKF-38393 hydrochloride

Name: (±)-SKF-38393 hydrochloride
Brand: SIGMA

≥98% (HPLC), D1 dopamine receptor agonist, crystalline

Synonym(s):

(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₇NO₂ · HCl

CAS Number:

62717-42-4

Molecular Weight:

291.77

UNSPSC Code:

12352200

PubChem Substance ID:

24277907

NACRES:

NA.77

MDL number:

MFCD00069248

Assay:

≥98% (HPLC)

Form:

crystalline

Quality level:

100

Storage condition:

desiccated, protect from light

Pricing and availability is not currently available.

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Product Name

(±)-SKF-38393 hydrochloride, crystalline, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

crystalline

storage condition

desiccated, protect from light

color

white

solubility

H₂O: >5 mg/mL, aqueous base: soluble (unstable)

SMILES string

Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1O

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H

InChI key

YEWHJCLOUYPAOH-UHFFFAOYSA-N

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Bioactive Small Molecules

Bioactive Small Molecule Agonists

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Show Differences

1 of 1

This Item	D054	S2816	S143
Sigma-Aldrich D047 (±)-SKF-38393 hydrochloride	Sigma-Aldrich D054 R(+)-SCH-23390 hydrochloride	Sigma-Aldrich S2816 SKF-83959 hydrobromide	Sigma-Aldrich S143 (±)-6-Chloro-PB hydrobromide
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form crystalline	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage condition desiccated, protect from light	storage condition desiccated, protect from light	storage condition -	storage condition desiccated
solubility H₂O: >5 mg/mL, aqueous base: soluble (unstable)	solubility H₂O: >5 mg/mL	solubility DMSO: >20 mg/mL, H₂O: insoluble	solubility H₂O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL
color white	color white	color white	color white to light tan

Application

(±)-SKF-38393 hydrochloride has been used as a selective D1 receptor agonist as a part of dopaminergic treatment. It has also been used to study its effect on prolactin in male baboons.

Biochem/physiol Actions

(±)-SKF-38393 is a D1 dopamine receptor agonist. It is known to promote the production of glutamate in the hippocampus.

Disclaimer

This material is hygroscopic. Air-sensitive. Light-sensitive.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000506644

0000465127

0000465125

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The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus

Bouron A and Reuter H

Neuroscience, 94(4), 1063-1070 (1999)

Prolactin and fMRI response to SKF38393 in the baboon

Miller B, et al.

PeerJ, 1(5), e195-e195 (2013)

Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish

Messias JPM, et al.

Proc. Royal Soc. Lond. B., 283(1823), 20152272-20152272 (2016)

Dopaminergic regulation of mate competition aggression and aromatase-Fos colocalization in vasotocin neurons.

David Kabelik et al.

Neuropharmacology, 58(1), 117-125 (2009-06-23)

Recent experiments demonstrate that aggressive competition for potential mates involves different neural mechanisms than does territorial, resident-intruder aggression. However, despite the obvious importance of mate competition aggression, we know little about its regulation. Immediate early gene experiments show that in

Dopamine disruption increases cleanerfish cooperative investment in novel client partners

Soares MC, et al.

Royal Society open science, 4(5), 160609-160609 (2017)

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