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CEP-701 hydrate

Name: CEP-701 hydrate
Brand: SIGMA

≥98% (HPLC), Flt-3 receptor tyrosine kinase inhibitor, powder

Synonym(s):

KT-5555 hydrate, Lestaurtinib hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₁N₃O₄ · xH₂O

CAS Number:

111358-88-4

Molecular Weight:

439.46 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329775153

NACRES:

NA.77

MDL number:

MFCD12828858

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

CEP-701 hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35

InChI

1S/C26H21N3O4.H2O/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28;/h2-9,18,30,32H,10-12H2,1H3,(H,27,31);1H2/t18-,25+,26+;/m1./s1

InChI key

LPOQWFBZBJTLEO-GMEYHWBASA-N

Description

Application

CEP-701 hydrate has been used as a tyrosine kinase inhibitor:

to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells[1]
as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4)[2]
as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia[3]

Biochem/physiol Actions

CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.[4]

CEP-701 is a Flt-3 receptor tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item	D9571	R5655	T2705
Sigma-Aldrich C7869 CEP-701 hydrate	Sigma-Aldrich D9571 Dolasetron mesylate hydrate	Sigma-Aldrich R5655 Rebamipide hydrate	Sigma-Aldrich T2705 Topotecan hydrochloride hydrate
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC and enzymatic)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. -	storage temp. −20°C
solubility DMSO: >10 mg/mL	solubility H₂O: >30 mg/mL	solubility DMSO: >5 mg/mL	solubility DMSO: ≥20 mg/mL
color white	color white to off-white	color white	color yellow

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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