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8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt

Name: 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

Rp-8-CPT-cGMPS, Rp-8-[(4-Chlorophenyl)thio]-cGMPS triethylammonium salt, Rp-8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3′,5′-hydrogen phosphorothioate triethylammonium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N

CAS Number:

276696-61-8

Molecular Weight:

605.07

NACRES:

NA.77

PubChem Substance ID:

329775000

UNSPSC Code:

41106305

MDL number:

MFCD04037247

Assay:

≥98% (HPLC)

Form:

solid

Pricing and availability is not currently available.

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Properties

biological source

synthetic

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 5 mg/mL

storage temp.

−20°C

SMILES string

CCN(CC)CC.NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5CO[P@@](O)(=S)O[C@H]5[C@H]4O)C(=O)N1

InChI

1S/C16H15ClN5O6PS2.C6H15N/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11;1-4-7(5-2)6-3/h1-4,8,10-11,14,23H,5H2,(H,25,30)(H3,18,20,21,24);4-6H2,1-3H3/t8-,10-,11-,14-,29-;/m1./s1

InChI key

KVOYZBYGWGWWTD-TXBWCVORSA-N

Description

Biochem/physiol Actions

Rp-8-CPT-cGMP is a potent inhibitor of protein kinase G Ia, Ib, and type II.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt is more cell permeable than Rp-cGMPS triethylamine.

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This Item	C0735	B6684	A166
Sigma-Aldrich C240 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt	Sigma-Aldrich C0735 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt	Sigma-Aldrich B6684 Rp-8-Bromo-β-phenyl-1,N²-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt	Sigma-Aldrich A166 Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt hydrate
form solid	form solid	form powder	form solid
assay ≥98% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 5 mg/mL	solubility -	solubility H₂O: 15 mg/mL at ≤60 °C	solubility H₂O: soluble
color white	color -	color white to beige	color white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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