C144
1-(3-Chlorophenyl)biguanide hydrochloride
solid
Synonym(s):
1-(m-Chlorophenyl)biguanide hydrochloride, N-(3-Chlorophenyl)imidodicarbonimidic diamide hydrochloride, m-CPBG hydrochloride
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About This Item
Linear Formula:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
CAS Number:
Molecular Weight:
248.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
Pricing and availability is not currently available.
form
solid
color
white
mp
190-194 °C (lit.)
solubility
H2O: soluble
SMILES string
Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1
InChI
1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
InChI key
FOWAIJYHRWFTHR-UHFFFAOYSA-N
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
Biochem/physiol Actions
Very potent 5-HT3 serotonin receptor agonist.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Borna Payandemehr et al.
Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
Zachary A Rodd et al.
The Journal of pharmacology and experimental therapeutics, 321(3), 1003-1012 (2007-02-28)
Studies from our laboratory indicated that local perfusion of the ventral tegmental area (VTA) with a serotonin-3 (5-HT(3)) receptor agonist increased dopamine (DA) neuronal activity and that the self-infusion of ethanol (EtOH) and cocaine into the posterior VTA could be
Jaime M Monti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(4), 940-947 (2008-02-26)
The effects of the selective 5-HT(3) receptor agonist and antagonist m-chlorophenylbiguanide (m-CPBG) and ondansetron, respectively, were studied in adult male Wistar rats implanted for chronic sleep recordings. Microinjection of m-CPBG (2.0 and 4.0 mM) into the dorsal raphe nucleus (DRN)