B8436

Anti-Brachyury antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-T brachyury-like, Anti-T, Anti-T Brachyury, mouse homolog, Anti-TFT, Anti-Transcription factor T
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 6

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, rat, mouse
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: 1:100-1:250, western blot: 1:500-1:1,000
• UniProt accession no.: O15178
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... T(6862) ; mouse ... T(20997) ; rat ... T(292301)

Description

General description

Brachyury (T) is an oncogene mapped to human chromosome 6q27. This gene codes for Brachyury, which is expressed throughout the primary mesoderm during the early stages of embryogenesis. Brachyury protein structure comprises highly conserved DNA binding domain, known as T-box domain.

Immunogen

synthetic peptide corresponding to an internal sequence of human brachyury (GeneID 6862). This sequence is 80% identical in mouse and 86% identical in rat.

Biochem/physiol Actions

Brachyury protein is a transcription factor that aids in the embryonic development of notochord tissue. It also plays an essential role in posterior mesoderm formation and differentiation. Brachyury is highly expressed in a variety of cancers including, chordoma and hemangioblastoma. It serves as an immunohistochemical marker for differential diagnosis of chordoma and hemangioblastoma (HBL).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable