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B6936

Sigma-Aldrich

3-Benzidino-6-(4-chlorophenyl)pyridazine

≥98% (HPLC), solid

Synonym(s):

BCP

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About This Item

Empirical Formula (Hill Notation):
C22H17N4Cl
CAS Number:
901773-91-9
Molecular Weight:
372.85
MDL number:
MFCD11046030
UNSPSC Code:
12352202
PubChem Substance ID:
329773289
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: >14 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ccc(cc1)-c2ccc(Nc3ccc(nn3)-c4ccc(Cl)cc4)cc2

InChI

1S/C22H17ClN4/c23-18-7-1-17(2-8-18)21-13-14-22(27-26-21)25-20-11-5-16(6-12-20)15-3-9-19(24)10-4-15/h1-14H,24H2,(H,25,27)

InChI key

ABGCSSPCKSVMHI-UHFFFAOYSA-N

Biochem/physiol Actions

3-Benzidino-6-(4-chlorophenyl)pyridazine is an inhibitor of delayed rectifier and transient outward potassium currents. The IC50 values for the blocking action of BCP on IKDR and IKA was calculated as 7.13 μM and 0.55 μM, respectively in acutely isolated rat hippocampal pyramidal neurons by using whole-cell patch-clamp technique. The parent compound, minaprine (Cat. No. M3157), has selective affinity for M1 muscarinic receptors and possesses memory-enhancing properties and also acts as an antidepressant.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecular biology and evolution, 34(5), 1083-1099 (2017-01-21)
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