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Key Documents

AV100732

Sigma-Aldrich

Anti-SOX8 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC24837, Anti-SRY (sex determining region Y)-box 8

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

47 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_055402

UniProt accession no.

P57073

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SOX8(30812)

General description

Sox8 belongs to the SoxE family of transcription factors that are critical for development of neural crest cells. The Sox gene family has been implicated in a number of developmental disorders.

Immunogen

Synthetic peptide directed towards the C terminal region of human SOX8

Application

Anti-SOX8 antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml.

Biochem/physiol Actions

Sox8 is expressed in Sertoli cells and regulates the spermatogenesis and spermatogenic cycle. Deficiency of Sox8 results in degeneration of adipose tissue and mild osteopenia.

Sequence

Synthetic peptide located within the following region: ASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGP

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Caroline E Haldin et al.
The international journal of biochemistry & cell biology, 42(3), 441-444 (2009-11-26)
Neural crest cells are the primary innovation that led to evolution of the vertebrates, and transcription factors of the SoxE family (Sox8, Sox9 and Sox10) are among the central players regulating the development of these cells. In all vertebrates examined
Moira K O'Bryan et al.
Developmental biology, 316(2), 359-370 (2008-03-18)
Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form group E of the Sox gene family which has been implicated in several human developmental disorders. In contrast to other SoxE genes
Sabine I E Guth et al.
Journal of lipid research, 50(7), 1269-1280 (2009-03-17)
Although the transcription factor Sox8 is broadly expressed during embryogenesis in developing ectodermal and mesodermal tissues, mice develop surprisingly normally in the absence of Sox8. Phenotypes in adult Sox8-deficient mice include mild osteopenia, late-onset male infertility, and reduced weight. We

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