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Key Documents

A7075

Sigma-Aldrich

Adrenocorticotropic Hormone rat

≥95% (HPLC)

Synonym(s):

Adrenocorticotropic hormone fragment 1-39, Corticotropin A

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About This Item

Empirical Formula (Hill Notation):
C210H315N57O57S
CAS Number:
77465-10-2
Molecular Weight:
4582.16
MDL number:
MFCD00167431
UNSPSC Code:
51111800
NACRES:
NA.32
biological source:
rat
form:
powder
Assay:
≥95% (HPLC)
Pricing and availability is not currently available.

biological source

rat

Quality Level

200

sterility

non-sterile

Assay

≥95% (HPLC)

form

powder

solubility

1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

P01194

shipped in

ambient

storage temp.

−20°C

Gene Information

rat ... Pomc(24664)

Related Categories

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Biochem/physiol Actions

Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.

Other Notes

Lyophilized from 0.1% TFA in H2O

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H351

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000386107
0000386107
0000386109
0000386109
0000253265

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Hasan Arrat et al.
PloS one, 10(5), e0125638-e0125638 (2015-05-09)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1
Carla Schulz et al.
American journal of physiology. Endocrinology and metabolism, 298(2), E237-E244 (2009-11-19)
ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH) are both consecutively processed from proopiomelanocortin (POMC), which is synthesized in hypothalamic arcuate neurons innervating the paraventricular nuclei (PVN). POMC secretion/synthesis is regulated by energy availability. ACTH and alpha-MSH bind with equal affinity to melanocortin-4

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