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A2504

Sigma-Aldrich

6-Aminocaproic acid

≥99% (titration), powder

Synonym(s):

ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

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About This Item

Linear Formula:
H2N(CH2)5CO2H
CAS Number:
60-32-2
Molecular Weight:
131.17
Beilstein:
906872
EC Number:
200-469-3
MDL number:
MFCD00008238
UNSPSC Code:
12352202
PubChem Substance ID:
24890662
NACRES:
NA.77

biological source

synthetic

Assay

≥99% (titration)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

mp

207-209 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

NCCCCCC(O)=O

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

InChI key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

Gene Information

human ... PLAT(5327) , PLG(5340)
rat ... Ppm1a(24666)

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Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

404.6 - 408.2 °F

Flash Point(C)

207 - 209 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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