A1354
APRIL human
recombinant, expressed in NSO cells, >95% (SDS-PAGE), lyophilized powder
Synonym(s):
A Proliferation-inducing Ligand, TALL-2, TNFSF13, TRDL-1
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About This Item
MDL number:
UNSPSC Code:
12352200
recombinant
expressed in NSO cells
Assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
23-25 kDa by SDS-PAGE (reducing)
calculated mol wt 18.6 kDa
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFSF13(8741)
Physical form
Lyophilized from a 0.2 μm filtered solution in PBS and 0.5 M NaCl, containing 50 μg BSA per 1 μg cytokine
Analysis Note
The biological activity is measured by its ability to induce proliferation of anti-IgM-stimulated human B cells. Alternatively, the activity can be measured by its ability to bind immobilized rhBCMA/Fc.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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K Kelly et al.
Cancer research, 60(4), 1021-1027 (2000-03-08)
We have examined the activity of a new member of the tumor necrosis factor (TNF) family identified through Expressed Sequence Tag database searching using TNFalpha protein as the search query. We have termed this protein TNF-related death ligand-la (TRDL-1alpha). Traditional
P A Moore et al.
Science (New York, N.Y.), 285(5425), 260-263 (1999-07-10)
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS
J A Gross et al.
Nature, 404(6781), 995-999 (2000-05-09)
B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cells. zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor
P Schneider et al.
The Journal of experimental medicine, 189(11), 1747-1756 (1999-06-08)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF
M Hahne et al.
The Journal of experimental medicine, 188(6), 1185-1190 (1998-09-22)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are
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