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N-Acetyl-Asp-Glu-Val-Asp-al

Name: N-Acetyl-Asp-Glu-Val-Asp-al
Brand: SIGMA

≥95%, powder

Synonym(s):

Ac-DEVD-CHO

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₀N₄O₁₁

CAS Number:

169332-60-9

Molecular Weight:

502.47

NACRES:

NA.32

PubChem Substance ID:

24890193

UNSPSC Code:

12352209

MDL number:

MFCD00671412

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Properties

biological source

synthetic

Quality Segment

100

assay

≥95%

form

powder

color

white

solubility

H₂O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

Description

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

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This Item	A6339	A1086	A5930
Sigma-Aldrich A0835 N-Acetyl-Asp-Glu-Val-Asp-al	Sigma-Aldrich A6339 N-Acetyl-Val-Glu-Ile-Asp-al	Sigma-Aldrich A1086 N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin	Sigma-Aldrich A5930 N-Acetyl-Asp-Glu
description ≥95%, powder	description ~99% (HPLC), powder	description ≥97% (HPLC), powder	description ≥97% (TLC)
biological source synthetic	biological source -	biological source -	biological source -
assay ≥95%	assay ~99% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (TLC)
Gene Information human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)	Gene Information human ... CASP6(839)	Gene Information -	Gene Information human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907), GRM3(2913) mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168), GRM3(108069) rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668), GRM3(24416)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 200
form powder	form powder	form powder	form powder or crystals
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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