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449R-1

Sigma-Aldrich

S100 beta (EP32) Rabbit Monoclonal Primary Antibody

Synonym(s):

S100 Calcium Binding Protein B

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP32, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (449R-14)
vial of 0.1 mL concentrate Research Use Only (449R-14-RUO)
vial of 0.5 mL concentrate (449R-15)
vial of 1.0 mL concentrate (449R-16)
vial of 1.0 mL concentrate Research Use Only (449R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (449R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (449R-17)
vial of 7.0 mL pre-dilute ready-to-use (449R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (449R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

S100 calcium binding protein B (S100 beta) is a member of the multifunctional S100 family of proteins. S100 beta acts as a stimulator of proliferation and migration and as an inhibitor of apoptosis and differentiation in many cell types including astrocytes, Schwann cells, chondrocytes, adipocytes, certain neuronal populations, melanocytes, Langerhans cells, histiocytes, epithelial, and myoepithelial cells. S100 beta is also expressed in neoplasms derived from these cell types, making it a useful marker for the identification of melanoma and various nervous system tumors. Although ubiquitous, S100 beta has proven to be a sensitive marker for malignant melanoma, including desmoplastic and metastatic variants.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R Donato et al.
Current molecular medicine, 13(1), 24-57 (2012-07-28)
The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects. S100 proteins are only expressed
F Sedaghat et al.
Hippokratia, 12(4), 198-204 (2009-01-23)
The members of the S100 protein family are multifunctional proteins with a regulatory role in a variety of cellular processes. They exert their actions usually through calcium binding, although Zn2+ and Cu2+ have also been shown to regulate their biological
C deBlacam et al.
British journal of cancer, 105(1), 118-123 (2011-06-10)
Cutaneous melanoma is an aggressive disease. S100beta is an established biomarker of disease progression; however, the mechanism of its regulation in melanoma is undefined. Expression of HOXC11 and SRC-1 was examined by immunohistochemistry and immunofluorescence. Molecular and cellular techniques were
Markku Miettinen et al.
The American journal of surgical pathology, 38(3), 410-420 (2014-02-15)
The SALL4 transcription factor is associated with embryonic cell pluripotency and has been shown as a useful immunohistochemical marker for germ cell tumors. However, information of SALL4 distribution in normal human tissues and non-germ cell tumors is limited. In this

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