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Key Documents

30153

Sigma-Aldrich

Potassium 2-mercaptoethanesulfonate

≥95% (T)

Synonym(s):

2-Mercaptoethanesulfonic acid potassium salt, Coenzyme M potassium salt, MES potassium salt

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About This Item

Linear Formula:
HSCH2CH2SO3K
CAS Number:
Molecular Weight:
180.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

≥95% (T)

storage temp.

−20°C

SMILES string

[K+].[O-]S(=O)(=O)CCS

InChI

1S/C2H6O3S2.K/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1

InChI key

XXZMREMZWJKGRQ-UHFFFAOYSA-M

Application

2-Mercaptoethanesulfonic acid salts (Coenzyme M potassium salt, MESK) are used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide and to prevention of brain injury damage.

Biochem/physiol Actions

Metabolite in microbial metabolism in diverse environments and methane metabolism ; methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methano-genesis; can be determined with chemiluminescence detection by flow injection analysis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A A Garcia
The Annals of pharmacotherapy, 29(6), 590-591 (1995-06-01)
To report a case of possible ifosfamide-induced Fanconi syndrome in and adult with cancer. A 20-year old man was treated for an osteosarcoma with a chemotherapy regimen that included ifosfamide, methotrexate, and doxorubicin. Three months after completing therapy he developed
M J Wargovich et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 5(5), 355-360 (1996-05-01)
We assessed the effects of 41 potential chemopreventive agents in the F344 rat using the inhibition of carcinogen-induced aberrant crypt foci (ACF) in the colon as the measure of efficacy. ACF were induced by the carcinogen azoxymethane in F344 rats
L F Capitán-Vallvey et al.
Talanta, 51(6), 1155-1161 (2008-10-31)
A flow injection method with chemiluminescence (CL) detection is proposed for the determination of sodium 2-mercaptoethane sulfonate (MESNA), a drug often used to reduce the urotoxic effects of antineoplastic alkylating agents. The procedure is based on the reaction of the
The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats.
Yilmaz ER, Kertmen H, et al.
Acta Neurochirurgica (2012)

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