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T0781

Supelco

3,5,5,-Trimethyloxazolidine-2,4-dione

analytical standard

Synonym(s):

Trimethadione

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About This Item

Empirical Formula (Hill Notation):
C6H9NO3
CAS Number:
127-48-0
Molecular Weight:
143.14
EC Number:
204-845-8
MDL number:
MFCD00047084
UNSPSC Code:
41116107
PubChem Substance ID:
329826621
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(=O)OC(C)(C)C1=O

InChI

1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3

InChI key

IRYJRGCIQBGHIV-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H312 + H332,H360

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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E Tanaka et al.
Journal of clinical pharmacy and therapeutics, 28(6), 493-496 (2003-12-04)
Trimethadione (TMO), an antiepileptic drug, may be used as a candidate for estimating hepatic drug-oxidizing activity. While TMO metabolism is mainly catalysed by CYP2C9, CYP2E1 and CYP3A4 the contribution of the different isoforms is unclear. In this study, we determined
N Kurata et al.
Xenobiotica; the fate of foreign compounds in biological systems, 28(11), 1041-1047 (1999-01-08)
1. Caucasian liver samples were used in this study. N-demethylation of trimethadione (TMO) to dimethadione (DMO) was monitored in the presence of chemical inhibitors of CYPs, such as fluconazole, quinidine, dimethyl-nitrosamine, acetaminophen, phenacetin, chlorzoxazone and mephenytoin. Trimethadione N-demethylation was selectively
Matthew E Barton et al.
European journal of pharmacology, 521(1-3), 79-85 (2005-09-21)
The purpose of the present study was to explore the analgesic effects of the low voltage-activated T-type Ca2+ channel blockers ethosuximide, trimethadione, and mibefradil in persistent and acute nociceptive tests. The anticonvulsant effects of the compounds were also determined in
James J Collins et al.
Experimental gerontology, 41(10), 1032-1039 (2006-07-29)
The identification and analysis of compounds that delay aging and extend lifespan is an important aspect of gerontology research; these studies can test theories of aging, lead to the discovery of endogenous systems that influence aging, and establish the foundation
Tammye L Fleeman et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 71(3), 185-190 (2004-07-30)
Congenital membranous ventricular septal defects (VSD) have been shown to close during postnatal development in rats [Solomon et al., Teratology 55:185-194, 1997]. Although they may differ in size, spontaneous and treatment-related VSD are histologically similar; however, the postnatal fate of
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