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Supelco

Synephrine

analytical standard

Synonym(s):

1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol

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About This Item

Empirical Formula (Hill Notation):
C9H13NO2
CAS Number:
Molecular Weight:
167.21
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤12.0% water (Karl Fischer)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

InChI

1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

InChI key

YRCWQPVGYLYSOX-UHFFFAOYSA-N

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General description

Synephrine is a sympathomimetic amine from the plant Citrus aurantium and is identified as a major active component of dietary supplements.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Synephrine may be used as a reference standard for the determination of synephrine in dietary supplements using high-performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.

Analysis Note

identification (GC-MS): identity conforms

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.
Slezak T, et al.
Analytica Chimica Acta, 593(1), 98-102 (2007)
Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.
Bouchard CN, et al.
Mayo Clinic Proceedings. Mayo Clinic, 80(4), 541-545 (2005)
Sidney J Stohs et al.
Phytotherapy research : PTR, 25(10), 1421-1428 (2011-04-12)
Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management as well as in sports performance products. However, questions are raised frequently regarding the safety of these ingredients. The potential
Sidney J Stohs et al.
International journal of medical sciences, 9(7), 527-538 (2012-09-20)
This review summarizes the published as well as unpublished human studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine, providing information and an assessment of the safety and efficacy of these widely used products. The results of
Luciana Grazziotin Rossato et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(1), 8-16 (2010-11-16)
Synephrine is cited as 'the active component' of plants and dietary supplements used in weight loss. It became one of the most popular stimulants present in weight-loss products after the US Food and Drug Administration had interdicted the use of

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