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32553

Supelco

Tinidazole

VETRANAL®, analytical standard

Synonym(s):

1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole

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About This Item

Empirical Formula (Hill Notation):
C8H13N3O4S
CAS Number:
19387-91-8
Molecular Weight:
247.27
Beilstein:
618182
EC Number:
243-014-4
MDL number:
MFCD00057217
UNSPSC Code:
41116107
PubChem Substance ID:
329754026
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CCS(=O)(=O)CCn1c(C)ncc1[N+]([O-])=O

InChI

1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3

InChI key

HJLSLZFTEKNLFI-UHFFFAOYSA-N

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General description

Tinidazole belongs to the family of nitroimidazole compounds.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tinidazole may be used as an analytical reference standard for the determination of the analyte in:
  • Tablet formulations and human serum samples by reversed phase-high performance liquid chromatography (RP-HPLC).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H312 + H332,H341,H351

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2 - Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3896
BCCC5372
BCBZ8493
BCBV9140
SZBF076XV

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Separation and assay o f antiprotozoal imidazole derivatives (metronidazole, tinidazole and secnidazole) by RP-HPLC.
Alhalabi Z, et al.
International Journal of Pharmaceutical Sciences Review and Research, 13(1), 13-18 (2012)
Alessandro Federico et al.
Gastroenterology, 143(1), 55-61 (2012-04-10)
Helicobacter pylori have become resistant to antimicrobial agents, reducing eradication rates. A 10-day sequential regimen that contains levofloxacin was efficient, safe, and cost saving in eradicating H pylori infection in an area with high prevalence of clarithromycin resistance. We performed
Elizabeth A Bosserman et al.
Sexually transmitted diseases, 38(10), 983-987 (2011-09-22)
Antimicrobial resistance is one of the causes of treatment failure in women after standard nitroimidazole therapy for Trichomonas vaginalis infections. The Centers for Disease Control and Prevention provides drug susceptibility testing and guidance for treatment failures but the efficacy of
Multi-residue method for the detection of veterinary drugs in distillers grains by liquid chromatography-Orbitrap high resolution mass spectrometry.
Kaklamanos G, et al.
Journal of Chromatography A, 1322, 38-48 (2013)
Horatio B Fung et al.
Clinical therapeutics, 27(12), 1859-1884 (2006-03-02)
Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration
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