All Photos(1)
About This Item
Linear Formula:
N3C6H4NCS
CAS Number:
Molecular Weight:
176.20
Beilstein:
6391971
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Assay
≥97.0% (CHN)
mp
65-68 °C (lit.)
66-68 °C
storage temp.
2-8°C
SMILES string
[N-]=[N+]=Nc1ccc(cc1)N=C=S
InChI
1S/C7H4N4S/c8-11-10-7-3-1-6(2-4-7)9-5-12/h1-4H
InChI key
XMPGXADJZXSISQ-UHFFFAOYSA-N
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Other Notes
Heterobifunctional crosslinking agent which forms a crosslink over a range of 10 Å and is expected to facilitate the investigation of hydrophobically interacting sites between proteins and membrane lipids
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Methods in Enzymology, 88, 207-207 (1982)
H. Sigrist et al.
Febs Letters, 113, 307-307 (1980)
Songlin Xu et al.
International journal of pharmaceutics, 404(1-2), 205-210 (2010-11-09)
Staudinger ligation was evaluated as a strategy for synthesizing receptor targeted liposomes. First, an activated lipid derivative was synthesized by reacting dioleoyl phosphatidylethanolamine (DOPE) and 2-(diphenylphosphino) terephthalic acid 1-methyl 4-penta-fluorophenyldiester. Second, transferrin (Tf) was activated with p-azidophenyl isothiocyanate. Third, liposomes
H Sigrist et al.
European journal of biochemistry, 125(1), 197-201 (1982-06-15)
Two hydrophobic, heterobifunctional azidoarylisothiocyanates have been synthesized. The reagents are applicable for group-directed modification of membrane-integrated protein segments and subsequent photo-induced cross-linking with neighbouring membrane constituents. Both 5-isothiocyanato-1-naphthalene azide and p-azidophenylisothiocyanate are chemically characterized with respect to structure and photosensitivity.
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