557354
ROS Inhibitor, YCG063
The ROS Inhibitor, YCG063, also referenced under CAS 330997-95-0, controls the biological activity of ROS.
Synonym(s):
ROS Inhibitor, YCG063, YCG063ROS Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C19H25N5O4S
CAS Number:
Molecular Weight:
419.50
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 50 mg/mL
ethanol: soluble
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤ 10 µM) in HepG2 and other cells, and suppresses cellular growth (≤ 50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤ 10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM). dose-dependently.
A cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤10 µM) in HepG2 and other cells, and suppresses cellular growth (≤50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM) dose-dependently.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kim, K.H., et al. 2011. Biochem. Biophys. Res. Commun.404, 541.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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