14-937-M

ALK2, active

• UNSPSC Code: 12352200
• eCl@ss: 32160405
• NACRES: NA.28

Properties

• recombinant: expressed in baculovirus infected Sf21 cells
• Quality Level: 100
• purified by: immobilized metal affinity chromatography (IMAC)
• technique(s): activity assay: suitable
• UniProt accession no.: Q04771
• Gene Information: human ... ACVR1(90)

Description

General description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Packaging

Also available in 10μg size as catalog # 14-937 and in bulk as catalog # 14-937-K.

Also available in 250μg size as catalog # 14-937M and in bulk as catalog # 14-937-K.

Quality

Routinely evaluated by phosphorylation of casein

Physical properties

45 kDa

Physical form

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Storage and Stability

6 months at -70°C

Analysis Note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.