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D-063

Supelco

Dehydroepiandrosterone (DHEA) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Dehydroepiandrosterone

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About This Item

Empirical Formula (Hill Notation):
C19H28O2
CAS Number:
53-43-0
Molecular Weight:
288.42
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChI key

FMGSKLZLMKYGDP-USOAJAOKSA-N

Related Categories

General description

DHEA is an endogenous steroid that has been implicated in a broad range of biological effects in humans and other mammals. Besides testing under the World Anti-Doping Code of the World Anti-Doping Agency (WADA), DHEA levels are also measured for newborn screening of congenital adrenal hyperplasia (CAH) and for determination of hyperandrogenic conditions such as polycystic ovarian syndrome and adrenal tumors. This calibration material is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.

Application

  • DHEA in Doping-Control: This research develops an extraction and GC-MS analysis method for anabolic steroids, including DHEA, in dietary supplements, aimed at doping control applications, enhancing the reliability of DHEA testing in sports science (Dahmani et al., 2018).
  • Chromatography for Hormonal Analysis: The development of a liquid chromatography-tandem mass spectrometry method for simultaneous measurement of testosterone, androstenedione, and DHEA in serum offers a robust tool for researchers studying steroid hormone pathways and their implications in various physiological processes (Xu et al., 2017).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marta Kokot-Kierepa et al.
Ginekologia polska, 83(10), 772-777 (2013-02-07)
With increasing longevity in Poland, women can now expect to live around 40% of their lives after menopause, and there is a growing desire for older women to preserve their vitality sexual function and quality of life. The most common
Jean-Pierre Savineau et al.
Biochemical pharmacology, 85(6), 718-726 (2012-12-29)
Dehydroepiandrosterone (DHEA) is a steroid hormone derived from cholesterol synthesized by the adrenal glands. DHEA and its 3β-sulphate ester (DHEA-S) are the most abundant circulating steroid hormones. In human, there is a clear age-related decline in serum DHEA and DHEA-S
Elizabeth Huerta-García et al.
BioMed research international, 2013, 382058-382058 (2013-03-14)
Particulate matter (PM) and nanoparticles (NPs) induce activation and dysfunction of endothelial cells characterized by inhibition of proliferation, increase of adhesion and adhesion molecules expression, increase of ROS production, and death. DHEA has shown anti-inflammatory and antioxidant properties in HUVEC
E Borman et al.
Clinical and experimental obstetrics & gynecology, 39(4), 429-431 (2013-03-01)
To determine if in a population of women with diminished oocyte reserve as evidenced by day 3 serum follicle stimulating hormone (FSH) levels > 12 mIU/ml women with lower dehydroepiandrosterone sulfate (DHEA-s) levels produce fewer oocytes or have lower pregnancy
Abdallah Alzoubi et al.
American journal of physiology. Heart and circulatory physiology, 304(12), H1708-H1718 (2013-04-16)
Current therapy of pulmonary arterial hypertension (PAH) is inadequate. Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in chronically hypoxic and monocrotaline-injected rats. Contrary to these animal models, SU5416/hypoxia/normoxia-exposed rats develop a more severe form of occlusive pulmonary arteriopathy and right
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