SML2953

MGR1

≥98% (HPLC)

• Synonym(s): 2,2-Dimethylpropanoic acid [(1,4,4a,9,9a,10-hexahydro-9,10-dioxo-1,4-ethanoanthracen-5-yl)oxy]methyl ester, JCHD precursor
• Empirical Formula (Hill Notation): C₂₂H₂₄O₅
• CAS Number: 2361529-46-4
• Molecular Weight: 368.42
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1C2C(C(C3=C1C=CC=C3OCOC(C(C)(C)C)=O)=O)C4C=CC2CC4

Description

Biochem/physiol Actions

MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μM). MGR1 is activated by intracellular esterases to form JCHD (5-hydroxy-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione), which in turn, facilitated by a proximal H-bonding hydroxyl group, undergoes keto-enol tautomerism for enhanced superoxide (O2•-) generation upon reacting with molecular oxygen (O2). MGR1, but not its inactive analog MGR2, upregulates cellular ROS, resulting in cell death when used at high concentrations (>5 μM; RAW264.7, THP1, HeLa, MCF7, A549).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable