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Key Documents

SAB4502956

Sigma-Aldrich

Anti-TGF β2, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Cetermin, G-TSF, Polyergin, TGFB2, Transforming growth factor β-2

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About This Item

MDL number:
MFCD01634324
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100

NCBI accession no.

P61812

UniProt accession no.

P61812

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGFB2(7042)

General description

Anti-TGF β2 Antibody detects endogenous levels of total TGF β2 protein.
Transforming growth factor-β2 (TGFB2) gene codes for the transforming growth factor β2 (TGFβ2).( β (TGF-β) protein superfamily. TGFB2 gene is mapped to human chromosome 1q41.

Immunogen

The antiserum was produced against synthesized peptide derived from human TGF beta2.

Immunogen Range: 361-410

Application

Anti-TGF β2, C-Terminal antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Transforming growth factor-β2 (TGFB2) protein plays a key role in transforming growth factor-β (TGF-β) signaling pathway. It aids in binding several TGF-β receptors to recruit and stimulate the others against decapentaplegic homolog SMAD protein family. TGF-β2 is involved in the proliferation and metastasis of glioma cells. It is implicated in metabolic syndrome (MetS). Single-nucleotide polymorphisms (SNPs) in TGFB2 are also associated with end-stage renal disease and conotruncal heart defects.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eugene Lin et al.
Scientific reports, 7(1), 13589-13589 (2017-10-21)
The transforming growth factor-β (TGF-β) signaling pathway and its relevant genes have been correlated with an increased risk of developing various hallmarks of metabolic syndrome (MetS). In this study, we assessed whether the TGF-β signaling pathway-associated genes of SMAD family
Mustafa Becerikli et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 40(8), 1810-1826 (2021-11-15)
Bone regeneration and fracture healing are impaired in diabetic patients due to defective functions of associated cells. Thus, the search for molecular causes and new treatment strategies are of particular clinical relevance. We investigated the gene expression profile of bones
Kejuan Song et al.
Oncology reports, 39(5), 2063-2070 (2018-03-08)
Ovarian cancer is a highly metastatic malignancy and a leading cause of cancer-related death in postmenopausal women. Emodin is a natural anthraquinone isolated from several traditional Chinese medicines including Rhubarb and Polygonum cuspidatum. Recently, emodin was demonstrated to reduce the growth

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