Skip to Content
Merck
All Photos(7)

Documents

HPA023644

Sigma-Aldrich

Anti-STAR antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1

Synonym(s):

Anti-NET29, Anti-STARD1, Anti-TMPIT, Anti-steroidogenic acute regulatory protein

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: 1:200-1:500

immunogen sequence

QDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELA

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... STAR(6770)

General description

Steroidogenic acute regulatory protein is located on human chromosome 8p11.2.

Immunogen

steroidogenic acute regulatory protein recombinant protein epitope signature tag (PrEST)

Application

Anti-STAR antibody produced in rabbit has been used to detect StAR in Paraffin-embedded adrenal samples using immunohistochemistry.

Biochem/physiol Actions

Steroidogenic acute regulatory protein (StAR) is essential for the transfer of cholesterol to mitochondria for adrenal and gonadal steroidogenesis. StAR gene analysis can help in the diagnosis of lipoid congenital adrenal hyperplasia (LCAH). It is also identified that activins A,B,AB downregulates StAR and thereby reduces the production of progesterone in human granulosa cells. Hypoxia mediated upregulation of StAR stimulates the synthesis of aldosterone in pulmonary artery endothelial cells which contributes to pulmonary vascular fibrosis. Activation of StAR helps in prevention of atherosclerotic cardiovascular disease.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST76259

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Clinical features and StAR gene mutations in children with congenital lipoid adrenal hyperplasia
Xie, Ting, et al.
Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 17(5), 472-476 (2015)
Role of the steroidogenic acute regulatory protein in health and disease
Manna, Pu, et al.
Endocrine, 51(1), 7-21 (2016)
The emerging role of the molecular marker p27 in the differential diagnosis of adrenocortical tumors
Pereira,, et al.
Endocrine Connections, EC-13 (2013)
Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis
Maron, Br, et al.
Circulation, CIRCULATIONAHA-CIRCULATION113 (2014)
Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1
Tugaeva,, et al.
Biochemical and Biophysical Research Communications, 497(1), 58-64 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service