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F4021
Follicle Stimulating Hormone from human pituitary
~7,000 IU/mg (powder)
Synonym(s):
FSH, Follitropin
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About This Item
biological source:
human pituitary glands
form:
powder
Pricing and availability is not currently available.
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biological source
human pituitary glands
Quality Level
sterility
non-sterile
form
powder
specific activity
~7,000 IU/mg (powder)
mol wt
35 kDa
technique(s)
cell culture | mammalian: suitable
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
pH
7.4
solubility
water: ~50 g/L
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... FSHB(2488) , FSHR(2492)
General description
The α chain of FSH has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.[1]
Research area: Cell signaling
Research area: Cell signaling
Application
Follicle stimulating hormone (FSH) from human pituitary has been used for-
Biochem/physiol Actions
FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle-stimulating hormone receptor) interacts with FSH in the ovaries and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis.[7] In the Caucasian population, certain polymorphisms in the FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS).[8] In the male fetuses and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.[9]FSH upon binding to its receptor FSH-R positively regulates G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to cascade intracellular signals.[10]
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
Packaging
Package size based on protein content
Other Notes
Two-chain glycoprotein hormone
Quality
Vial also contains 0.1 mg of salts from 0.05 M phosphate buffer, pH 7.4.
antibody
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Karenne N Fru et al.
Biology of reproduction, 75(4), 568-574 (2006-07-14)
Ovulation and luteal formation in primates are associated with the sustained synthesis of progesterone. The observed high intrafollicular concentrations of progesterone during the periovulatory interval raise the possibility that this steroid serves as a precursor for mineralocorticoids. The aim of
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation
Mahamud-Ur Rashid et al.
PLoS neglected tropical diseases, 14(6), e0008335-e0008335 (2020-06-09)
Zika virus (ZIKV), a neglected tropical disease until its re-emergence in 2007, causes microcephaly in infants and Guillain-Barré syndrome in adults. Its re-emergence and spread to more than 80 countries led the World Health Organization in 2016 to declare a
Marina Grigorova et al.
The Journal of clinical endocrinology and metabolism, 96(9), E1534-E1541 (2011-07-08)
The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly
Stine Gry Kristensen et al.
The Journal of clinical endocrinology and metabolism, 104(12), 6371-6384 (2019-07-10)
Members of the TGF-β family have been implicated in aberrant follicle development in women with polycystic ovaries (PCO). Are there quantitative differences in the concentrations of TGF-β family members in fluid from human small antral follicles (hSAFs) in women with
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What is the Department of Transportation shipping information for this product?
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Do you have information on the solution stability of Follicle Stimulating Hormone (FSH) from pituitary?
1 answer-
For information on the solution stability of FSH (and much more), refer to Chem. Soc. Rev., 2(4), 355-395 (1973).From page 369: "The stabilities of the most highly purified preparations of certain hormonal glycoproteins have presented some problems, e.g. follicle-stimulating hormone preparations are often found to be stable in frozen solution but lose activity dramatically on concentration and freeze drying." Based on that information, we would recommend that if you need to freeze solutions of FSH, you should flash-freeze the solution (using either liquid nitrogen or a dry ice-alcohol bath), and store the solution in the ultra-cold (-70 or -80°C) freezer. Since FSH does have some solution stability concerns, simply placing the solution in a -20°C freezer without first flash-freezing may reduce the activity.
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For Product F4021, Follicle Stimulating Hormone, do you have information on reconstitution, solution storage and potency?
1 answer-
Product F4021-1VL is packaged as 50 units/vial. Each vial contains roughly 35-36 milligrams solid. Our solubility testing is done at 50 mg/mL, which yields a slightly hazy solution. It may be more convenient to use units/mL for your experiment as it will be more precise. If you decide to try to weigh out the material, please realize that small quantities can be difficult to weigh accurately.For Product F4021, FSH from human pituitary, we recommend solution storage for up to one month at 2-8°C. Unfortunately, we do not have any Sigma data regarding the stability of the porcine hormone.In the absence of information, we would recommend that solutions of Product F4021 not be frozen. If you do decide to store the product at -20°C we would suggest storing it in single use aliquots to avoid numerous freeze/thaw cycles.For the human FSH product we list an approximate activity of 7000 International Units/milligram. This should provide you with a starting point for a conversion calculation. For the porcine product we do not provide a conversion for units to mass. We provide 50 Armour units per vial. The unit definitions are also slightly different. International units are based on an international standard (IRP-68/140) while Armour units are based on Armour FSH standard G-94. According to the literature, 1 Armour unit can contain 9.4-14.2 international units.
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