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E3625

Sigma-Aldrich

16-Epiestriol

≥93% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-3,16β,17β-triol, 16β-Hydroxy-17β-estradiol, 3,16β,17β-Trihydroxy-1,3,5(10)-estratriene

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About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
547-81-9
Molecular Weight:
288.38
EC Number:
208-937-9
MDL number:
MFCD00067609
UNSPSC Code:
12352202
PubChem Substance ID:
24894522
NACRES:
NA.77

Quality Level

200

Assay

≥93% (HPLC)

form

powder

solubility

ethanol: 0.98-1.02 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC12CCC3C(CCc4cc(O)ccc34)C1CC(O)C2O

InChI

1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3

InChI key

PROQIPRRNZUXQM-UHFFFAOYSA-N

Biochem/physiol Actions

16-Epiestriol is found naturally in various animals, plants, and fungal yeast. It potentially inhibits the growth of colistins and carbapenem-resistant A. baumannii
16-Epiestriol, an estradiol metabolite, possesses anti-inflammatory properties but no glycogenic properties.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xia Xu et al.
Genome medicine, 4(4), 31-31 (2012-05-02)
Endogenous estrogens and estrogen metabolites play an important role in the pathogenesis and development of human breast, endometrial, and ovarian cancers. Increasing evidence also supports their involvement in the development of certain lung, colon and prostate cancers. In this study
Sally B Coburn et al.
Cancer causes & control : CCC, 30(1), 75-86 (2018-12-07)
The comparability between serum, plasma, and urinary measurements of estrogen metabolites via liquid chromatography-tandem mass spectrometry (LC-MS/MS) has not been largely explored, and it is unclear if urinary LC-MS/MS measurements are suitable surrogates of circulating levels. Serum, plasma (EDTA and
Ju-Yeon Moon et al.
BMC clinical pathology, 13(1), 25-25 (2013-10-26)
Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC). To evaluate the differential estrogen metabolism between benign and malignant PTCs, estrogen profiling by gas chromatography-mass spectrometry was applied to urine samples from postmenopausal patients with
Xiaoguang Sunny Li et al.
Talanta, 178, 464-472 (2017-11-16)
Accurate quantitation of estrogens (i.e, estrone (E1), estradiol (E2) and estriol (E3)) is valuable for clinical assessment of human health and disease. Alterations in estrogen levels have been implicated in numerous pathological conditions. However, inadequacies in sensitivity and specificity, cumbersome
Roni T Falk et al.
Breast cancer research : BCR, 15(2), R34-R34 (2013-04-24)
Elevated levels of circulating estrogens are linked to breast cancer risk among postmenopausal women but little is known about the importance of estrogen metabolism. A recently developed liquid chromatography tandem mass spectrometry-based method (LC-MS/MS) measuring a panel of 15 estrogen
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