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B5016

Sigma-Aldrich

Bepridil hydrochloride

powder

Synonym(s):

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C24H34N2O · HCl
CAS Number:
68099-86-5
Molecular Weight:
403.00
MDL number:
MFCD00065498
UNSPSC Code:
12352202
PubChem Substance ID:
24277824
NACRES:
NA.77

form

powder

originator

Johnson & Johnson

SMILES string

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChI key

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Gene Information

human ... CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283)

Biochem/physiol Actions

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Li et al.
The Journal of pharmacology and experimental therapeutics, 291(2), 562-568 (1999-10-19)
The effects of bepridil, a potent antiarrhythmic drug, on the activity of ATP-sensitive K(+) (K(ATP)) channels and Na(+)-activated K(+) (K(Na)) channels were examined in isolated patches from guinea pig ventricular myocytes. In inside-out membrane patches, K(ATP) channel currents were recorded
Hiroki Takanari et al.
Journal of pharmacological sciences, 115(1), 15-26 (2010-12-16)
Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated
Masato Murakami et al.
Journal of cardiovascular pharmacology, 56(4), 389-395 (2010-07-14)
It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the
Stefan Mitterreiter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(26), 8974-8983 (2010-07-02)
The two proteases beta-secretase and gamma-secretase generate the amyloid beta peptide and are drug targets for Alzheimer's disease. Here we tested the possibility of targeting the cellular environment of beta-secretase cleavage instead of the beta-secretase enzyme itself. beta-Secretase has an
Tsuyoshi Shiga et al.
Circulation journal : official journal of the Japanese Circulation Society, 75(6), 1334-1342 (2011-04-13)
It is unknown whether bepridil improves cardiovascular events in atrial fibrillation (AF) patients, so this study evaluated the clinical outcome in paroxysmal or persistent AF patients receiving bepridil. We conducted a cohort study of 284 consecutive patients who received bepridil
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