A4393

R-(−)-Apomorphine hydrochloride hemihydrate

calcined, ≥98.5% (with NaOH, titration)

• Linear Formula: C₁₇H₁₇NO₂ · HCl · 1/2H₂O
• CAS Number: 41372-20-7
• Molecular Weight: 312.79
• EC Number: 206-243-0
• MDL number: MFCD00150904
• UNSPSC Code: 12352210
• PubChem Substance ID: 24278821
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98.5% (with NaOH, titration)
• form: calcined; (Powder to Crystalline Powder)
• storage condition: protect from light; under inert gas
• color: white to gray
• mp: 285-287 °C (lit.)
• solubility: H₂O: ~10 mg/mL, clear, yellow-green
• SMILES string: Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68
• InChI: 1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
• InChI key: CXWQXGNFZLHLHQ-DPFCLETOSA-N
• Gene Information: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Description

Application

R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.

Biochem/physiol Actions

R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves