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PHR2033

Supelco

Rivastigmine Related Compound E

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(S)-1-(3-{[Ethyl(methyl)carbamoyl]oxy}phenyl)-N,N,N-trimethylethanaminium iodide

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About This Item

Empirical Formula (Hill Notation):
C15H25IN2O2
Molecular Weight:
392.28
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1604950

API family

rivastigmine

CofA

current certificate can be downloaded

packaging

pkg of 30 mg

application(s)

pharmaceutical

format

neat

storage temp.

-10 to -25°C

General description

Rivastigmine Related Compound E is an impurity of rivastigmine, a novel acetylcholine esterase inhibitor. It is mainly used for the treatment of Alzheimer′s disease.

Application

Rivastigmine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using electroanalytical technique and high-performance thin layer chromatography method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB4763 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Stability-indicating HPTLC determination of rivastigmine in the bulk drug and in pharmaceutical dosage forms
Karthik A, et al.
J. Planar Chromatogr.-Mod. TLC, 20(6), 457-461 (2007)
Voltammetric determination of rivastigmine in pharmaceutical and biological samples using molecularly imprinted polymer modified carbon paste electrode
Arvand M, et al.
Sensors and Actuators B, Chemical, 188, 797-805 (2013)

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