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biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse, rodent, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SOX1(6656)
Specificity
Reactivity with other species has not been confirmed.
Recognizes Sox-1, a high mobility group (HMG) transcription factor.
Immunogen
Synthetic peptide from human Sox1.
Application
Anti-Sox1 Antibody detects level of Sox1 & has been published & validated for use in WB, IH.
Research Sub Category
Neuronal & Glial Markers
Developmental Neuroscience
Neuronal & Glial Markers
Developmental Neuroscience
Western blot: 1:200-1:1,000 using ECL. Immunohistochemistry: 1:200-1:1,000. Optimal working dilutions must be determined by the end user.
Linkage
Replaces: AB5768
Physical form
Affinity purified immunoglobulin. Precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
Format: Purified
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Fabien Almairac et al.
Cancer research, 80(16), 3236-3250 (2020-05-06)
There is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here, we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise from original differentiated
Catarina M Seabra et al.
Molecular autism, 11(1), 45-45 (2020-06-07)
MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome sequencing studies have directly implicated MBD5 in the etiology of autism
Role of miRNAs in neuronal differentiation from human embryonic stem cell-derived neural stem cells.
Jing Liu et al.
Stem cell reviews and reports, 8(4), 1129-1137 (2012-10-12)
microRNAs (miRNAs) are important modulators in regulating gene expression at the post-transcriptional level and are therefore emerging as strong mediators in neural fate determination. Here, by use of the model of human embryonic stem cell (hESC)-derived neurogenesis, miRNAs involved in
Kiyohito Murai et al.
Nature communications, 7, 10965-10965 (2016-03-12)
Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor
Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.
Ying Pei et al.
Brain research, 1638(Pt A), 57-73 (2015-08-10)
Induced pluripotent stem cells (iPSC) and their differentiated derivatives offer a unique source of human primary cells for toxicity screens. Here, we report on the comparative cytotoxicity of 80 compounds (neurotoxicants, developmental neurotoxicants, and environmental compounds) in iPSC as well
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