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Key Documents

128201

Sigma-Aldrich

N-Ethyl-o-crotonotoluidide

97%

Synonym(s):

N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
Molecular Weight:
203.28
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

description

predominantly trans

Quality Level

Assay

97%

form

solid

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

solubility

ethanol: soluble
methanol: soluble

density

0.987 g/mL at 25 °C (lit.)

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

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Application

N-Ethyl-o-crotonotoluidide ( Crotamiton) was used to study the photocatalytic decomposition of crotamiton in aqueous solution using TiO2.
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
M COUPERUS
The Journal of investigative dermatology, 13(1), 35-42 (1949-07-01)
Demodecidosis manifested on the external genitalia.
S M Hwang et al.
International journal of dermatology, 37(8), 634-636 (1998-09-10)
N Nakada et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 61(7), 1739-1747 (2010-04-08)
The behavior of antibacterial triclosan, insect-repellent diethyltoluamide (DEET), anticonvulsant carbamazepine, and antipruritic crotamiton was investigated at two sewage treatment plants (STPs) to clarify their complete mass balance. Twenty-four-hour flow-proportional composite samples were collected from the influent and effluent of primary
Allergic contact dermatitis due to crotamiton.
H Hara et al.
Contact dermatitis, 49(4), 219-219 (2004-03-05)
Ulrich R Hengge et al.
The Lancet. Infectious diseases, 6(12), 769-779 (2006-11-25)
Scabies has been a scourge among human beings for thousands of years. Its worldwide occurrence with epidemics during war, famine, and overcrowding is responsible for an estimated 300 million people currently infested. Scabies refers to the various skin lesions produced

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