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U6625

Sigma-Aldrich

Uridine 5′-triphosphate trisodium salt hydrate

from yeast, Type III, ≥96%

Synonym(s):

UTP Na3

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About This Item

Empirical Formula (Hill Notation):
C9H12N2Na3O15P3 · xH2O
CAS Number:
19817-92-6
Molecular Weight:
550.09 (anhydrous basis)
Beilstein:
3585234
MDL number:
MFCD00044310
UNSPSC Code:
12352200
PubChem Substance ID:
24900436
NACRES:
NA.77

biological source

yeast

type

Type III

Assay

≥96%

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

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Application

UTP has been used to study its vasodilatory effects on the skeletal muscle cells of diabetic patients. UTP has also been used as a purinergic agonist to study ion transport functions of P2Y2 receptors on rat basolateral membranes.

Biochem/physiol Actions

P2Y receptor agonist.

Preparation Note

Uridine 5′-triphosphate trisodium salt (UTP Na3) hydrate dissolves in water at 50 mg/ml to yield a clear to slightly hazy, colorless solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Xiping Chen et al.
FEBS letters, 595(1), 110-122 (2020-10-25)
O-GlcNAcylation is a post-translational modification catalysed by O-GlcNAc transferase (OGT). Missense mutations in OGT have been associated with developmental disorders, OGT-linked congenital disorder of glycosylation (OGT-CDG), which are characterized by intellectual disability. OGT relies on the hexosamine biosynthetic pathway (HBP)
Satyanarayana R Pondugula et al.
BMC research notes, 3, 100-100 (2010-04-20)
The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracrine and autocrine hormones along with their associated intracellular signal
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Adelaine K W Leung et al.
Journal of molecular biology, 402(1), 154-164 (2010-07-21)
RNA is known to perform diverse roles in the cell, often as ribonucleoprotein (RNP) particles. While the crystal structure of these RNP particles could provide crucial insights into their functions, crystallographic work on RNP complexes is often hampered by difficulties
Kazuyuki Takai et al.
Nature protocols, 5(2), 227-238 (2010-02-06)
Biochemical characterization of each gene product encoded in the genome is essential to understand how cells are regulated. The bottleneck has been and still is in how the gene products can be obtained. The wheat cell-free protein synthesis system we
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