T4510

Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt

chromogenic, ≥98% (HPLC), powder

• Synonym(s): p-Nitrophenyl-5V-thymidine-monophosphate, p-Nph-5V-TMP
• Empirical Formula (Hill Notation): C₁₆H₁₈N₃O₁₀PNa
• CAS Number: 98179-10-3
• Molecular Weight: 466.29
• UNSPSC Code: 12352204
• PubChem Substance ID: 131888503
• NACRES: NA.32

Properties

• product name: Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• solubility: water: 50 mg/mL
• storage temp.: −20°C
• SMILES string: CC(C(N1)=O)=CN([C@H]2C[C@H](O)[C@@H](COP(O)(OC(C=C3)=CC=C3[N+]([O-])=O)=O)O2)C1=O.[Na]
• InChI: 1S/C16H18N3O10P.Na.H/c1-9-7-18(16(22)17-15(9)21)14-6-12(20)13(28-14)8-27-30(25,26)29-11-4-2-10(3-5-11)19(23)24;;/h2-5,7,12-14,20H,6,8H2,1H3,(H,25,26)(H,17,21,22);;
• InChI key: PHNRUCBIIRECII-UHFFFAOYSA-N

Description

Application

Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt has been used as a substrate for assessing phosphodiesterase activity. It is also been used as a nucleotide analog in the autotaxin inhibition assay.

Biochem/physiol Actions

Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt is an artificial substrate marker for 5′-nucleotide phosphodiesterase enzyme activity. It is also used as a substrate for autotaxin (ATX, NPP2), which is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) enzyme family.

Substrates

A sensitive chromogenic substrate for venom phosphodiesterase. It is not hydrolyzed by bovine spleen phosphodiesterase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable