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Key Documents

SRP8033

Sigma-Aldrich

IL-1β mouse

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

Synonym(s):

Interleukin-1beta, Postn

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

conjugate

untagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~17 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

immunohistochemistry: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P10749

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il1b(16176)

General description

Interleukin-1β (IL-1β) is produced by activated macrophages. It belongs to the IL-1 family of proteins that are involved in the inflammatory response.

Biochem/physiol Actions

Interleukin-1β (IL-1β) stimulates thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation and fibroblast growth factor activity. IL-1β, in most situations requires the inflammasome complex to be cleaved and secreted. This protein may modulate the effects of eosinophils in the intestine.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

Mouse IL-1beta (aa 118-269) is untagged.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Understanding the mechanism of IL-1? secretion.
Lopez-Castejon G and Brough D
Cytokine & Growth Factor Reviews, 22(4), 189-195 (2011)
Ruojia Ma et al.
Drug development research, 83(3), 735-744 (2021-12-21)
Type 2 diabetes mellitus (T2DM) is a metabolic risk factor associated with non-alcoholic liver disease (NAFLD). Schisandrin B (Sch B) is a promising agent for NAFLD. However, the actions of Sch B on diabetes-associated NAFLD and the underlying mechanisms are
IL-1? in eosinophil-mediated small intestinal homeostasis and IgA production.
Jung Y
Mucosal Immunology, 8(4), 930-942 (2015)
Dongmin Xu et al.
Experimental and therapeutic medicine, 23(1), 14-14 (2021-11-25)
Perfluorooctane sulfonate (PFOS) is a persistent pollutant that exerts toxicity and induces cardiogenesis in humans and animals. Yet, the effect of PFOS exposure on cardiac toxicity in adult rats has, to our knowledge, not been reported and the mechanism still
Hai-Lei Guo et al.
Inflammation, 44(1), 358-370 (2020-10-13)
The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an important role in the development of late-phase sepsis. However, in this study, we wanted to explore the possibility of using IL-1β to improve the prognosis of sepsis by
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