SML0982

Astaxanthin

from Blakeslea trispora, ≥97% (HPLC), powder, PPARγ

• Synonym(s): 3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin
• Empirical Formula (Hill Notation): C₄₀H₅₂O₄
• CAS Number: 7542-45-2
• Molecular Weight: 596.84
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Astaxanthin, ≥97% (HPLC), from Blakeslea trispora
• biological source: Blakeslea trispora
• Assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated; protect from light
• color: , pink to very dark purple
• solubility: DMSO: 1 mg/mL (warmed)
• storage temp.: −20°C
• InChI: 1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
• InChI key: MQZIGYBFDRPAKN-UWFIBFSHSA-N

Description

General description

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.

Application

Astaxanthin has been used:

• as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth
• to study its effects on the treatment of diabetic retinopathy.
• to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.

Biochem/physiol Actions

In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson′s disease. Due to its bright red colour, AST has been used as a food colorant in animal feeds.

Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

Other Notes

Light and air sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable